5-Amino-1MQ

5-Amino-1MQ Overview

5-Amino-1MQ is a specialized, membrane-permeable small molecule designed to selectively inhibit the nicotinamide N-methyltransferase (NNMT) enzyme. NNMT is primarily located in the cytosol and is a key player in cellular energy metabolism, especially within white adipose tissue and skeletal muscle. By targeting this enzyme, 5-Amino-1MQ prevents the depletion of methyl donors and facilitates a shift in how cells process energy. This inhibition has shown profound results in preclinical research, specifically in reducing the expansion of fat cells and enhancing the regenerative capacity of muscle fibers. It represents a significant area of study for addressing metabolic dysfunction and age-related physical decline.

5-Amino-1MQ Structure

Molecular Formula: C10H11N2

Molecular Weight: 159.21 grams per mole

Source: PubChem

Structure Solution Formula:

To prepare a laboratory-grade solution, combine 10 milligrams of 5-Amino-1MQ with 1 milliliter of high-purity dimethyl sulfoxide (DMSO). Gently agitate or sonicate the mixture until the powder is completely integrated and the solution is clear.

5-Amino-1MQ Research

Obesity

Obesity is a complex condition driven by a disruption in the body's natural energy balance. Research has identified that individuals with metabolic issues often exhibit unusually high levels of the NNMT enzyme. This enzyme acts as a metabolic "brake," slowing down the rate at which the body burns fat. In laboratory models, scientists have observed that when NNMT is inhibited, there is a corresponding increase in the glucose transporter known as GLUT4.

When GLUT4 levels are high, the body becomes more efficient at utilizing sugar for energy rather than storing it as adipose tissue. Studies on overweight rodents demonstrated that 5-Amino-1MQ administration led to a 40 percent reduction in the size of fat cells (adipocytes) within several weeks. Remarkably, these subjects achieved weight loss without a reduction in food consumption, suggesting that the compound enhances the basal metabolic rate.

Parameter

Impact of NNMT Inhibition

Fat Cell Volume

Significant Reduction

Glucose Uptake

Enhanced via GLUT4 Activation

Energy Expenditure

Increased Basal Rate

Lipid Accumulation

Decreased in Liver and Adipose

5-Amino-1MQ and Muscle Function

The role of 5-Amino-1MQ in muscle health is centered on its ability to stimulate muscle stem cells. As the body ages or suffers from chronic disease, NNMT levels in the muscle increase, which can lead to muscle wasting (sarcopenia). Research indicates that inhibiting NNMT can "awaken" these stem cells, promoting the repair and growth of muscle fibers. In aged mice, treatment with this compound resulted in a 70 percent increase in muscle cross-sectional area and a notable increase in grip strength, suggesting that 5-Amino-1MQ may protect against the frailty associated with aging and sedentary lifestyles.

A Possible Role for 5-Amino-1MQ in Cognition

Recent investigations have explored the link between metabolic health and brain function. Because 5-Amino-1MQ increases the availability of NAD+ within the system, it may provide neuroprotective benefits. NAD+ is essential for the energy production required by neurons to maintain synaptic plasticity. By preventing the depletion of this vital molecule, NNMT inhibitors may support neurogenesis and protect the neuromuscular junctions that allow the brain to communicate effectively with the body.

5-Amino-1MQ Summary

5-Amino-1MQ is a highly selective tool for the study of metabolic regulation. By blocking the NNMT enzyme, it effectively reconfigures cellular energy use, favoring fat oxidation and muscle preservation. Its ability to improve insulin sensitivity and body composition makes it a primary subject of interest in the fields of obesity research, sports science, and longevity medicine.