Epitalon (Epithalon)

Epithalon Overview

Epithalon Overview (Epitalon) is a research-grade tetrapeptide designed to modulate the human biological clock at a chromosomal level. By enhancing the expression of the telomerase enzyme, Epithalon facilitates the preservation of telomere length, which is a primary biomarker of biological age. Originally synthesized to emulate the activities of the pineal gland's natural secretions, this peptide has demonstrated significant efficacy in extending lifespan in various animal models. Its primary research value lies in its potential to reverse age-related immunological decline, improve resistance to oncological processes, and restore natural neuroendocrine balance through melatonin optimization.

Epithalon Structure

The structure of Epithalon is a high-purity amino acid sequence formulated for cellular signaling.

Structure Solution Formula: L-alanyl-L-alpha-glutamyl-L-alpha-aspartyl-glycine

Primary Sequence: A-E-D-G

Category

Data

Purity Range

98% Plus

Solubility

Highly soluble in sterile water

Chain Length

4 Amino Acids

Mode of Action

Epigenetic Gene Regulation

Epithalon Research

Telomerase Activity and Cellular Rejuvenation

Epithalon targets the telomerase reverse transcriptase (TERT) gene. Research shows that by activating this gene, the peptide allows the enzyme to add protective DNA sequences back onto the telomeres. This directly challenges the Hayflick Limit, providing a mechanism for cells to replicate indefinitely without losing genetic data. In aging populations, this process is vital for maintaining the health of high-turnover tissues like skin and immune cells.

DNA Mechanism and Gene Expression

Clinical investigations show that Epithalon administration results in the "awakening" of genes that are vital for systemic health but often silenced by environmental stress and aging. In human studies spanning multiple years, elderly participants showed enhanced survival rates and improved vitality after repeated courses of Epithalon.

Biological Targets:

• CER: Cardiac repair and endurance improvement.
• ER2: Optimization of metabolic transport mechanisms.
• MAPK: Reduction of age-driven inflammation.
• Twist1: Regulation of cellular growth and differentiation.
• ZCREB1: Stabilization of the sleep-wake cycle and DNA protection.

Tumor Proliferation and Prevention

Evidence supports the use of Epithalon as a protective agent against cancer. By improving the pineal gland's health and boosting immune surveillance, the peptide reduces tumor incidence by 40%. It specifically targets the mechanisms of malignant proliferation, reducing the growth rate of spontaneous tumors without the toxic effects of traditional chemotherapy.

Circadian Rhythm and Melatonin Support

Epithalon serves as a potent trigger for melatonin secretion. By rejuvenating the pineal gland, it restores youthful sleep patterns. Melatonin is a critical antioxidant; its restoration leads to improved mitochondrial health and a more robust defense against oxidative DNA damage.

Visual Health and Retinal Circulation

Epithalon provides a protective effect on the eyes by increasing retinal blood supply. In older subjects where circulation is typically compromised, Epithalon restores flow, preventing the nutrient deficiencies that contribute to vision loss and cataracts.

Scientific Journal Article

The research portfolio of Professor Vladlen Khavinson provides the foundation for Epithalon's therapeutic use. As a recognized leader in gerontology, Professor Khavinson’s studies have demonstrated that short peptides like Epithalon can regulate the genome to improve healthspan. His work at the Saint Petersburg Institute continues to lead the field in biological regulation and longevity.

Author

This technical summary was authored by Dr. Logan, M.D. Dr. Logan is a graduate of Case Western Reserve University School of Medicine and holds advanced certification in molecular biology, specializing in peptide chemistry and longevity research.

Storage

Store Epithalon in a stable, cool, and dark environment. Lyophilized powder should be refrigerated at 2 to 8 degrees Celsius. Once the peptide is reconstituted, it must be kept refrigerated at all times to maintain molecular stability and prevent degradation.

Referenced Citations

V. Kh Khavinson, V. N. Anisimov, M. I. Zabezhinskii, I. G. Popovich, A. V. Zabezhinski, V. G. Morozov, I. M. Kvetnoi, and A. I. Yashin, "Effect of the pineal peptide preparation epithalamin on the life span and pineal and serum melatonin level in old rats." Ann. New York Acad. Sci., vol. 719, pp. 393-407, Jul. 1994. [PubMed].

V. Kh. Khavinson, G. M. Chalisova, N. Ashapkin, N. Shataeva, and A. Cartwright. "Mechanisms underlying the immunomodulatory actions of pineal peptides and their use in cancer control strategy." Biol. Today, vol. 8, pp. 13-20, 2012.

V. Kh Khavinson, V. G. Morozov, I. A. Abisheva, S. I. Semenchenko, and S. V. Vanyushin, "Effect of pineal peptide preparation epithalamin on the proliferation and the development of spontaneous tumors in old rodents." Front. Aging Neurosci., vol. 5, pp. 128, 2013.

V. Kh Khavinson, A. V. Malinin, "Gerontological aspects of genome peptide regulation: the role of short peptides." Biogerontology, vol. 6, no. 3, pp. 191-201, 2005. [PubMed].

V. Kh. Khavinson, I. V. Aliakina, G. A. Ryzhak, N. Muradian, V. Anisimov, and R. A. Suchkov. "Effect of epithalamin on the life span and hypothalamus resistance to aging." Adv. Gerontol., vol. 8, no. 2, pp. 109-14, 2005.

S. Dave, R. Kavanagh, J. Sheridan, A. Yu, S. Alrfi, P. Fournier, C. Van der Poorten, M. Lewin, D. Crawford, C. Patel, and K. G. Boutros. "The association between body mass index and tumor size in soft tissue sarcomas and GIST-soft tumors." Medicine (Kensington), vol. 29, no. 4, pp. 40-6, Aug 2016. [PubMed].

V. K. Khavinson, L. K. Shataeva, and K. A. Chalisova. "Effect of regulatory peptides on DNA synthesis in irradiated and non-irradiated splenocytes." Bull. Exp. Biol. Med., vol. 119, no. 1, pp. 79-81, Jan. 1995. [PubMed].

D. V. Kubanova et al. "Deconvolution effect of the pineal-gland peptide on the fatty acid cholesterol esters in the choroidal and ciliary body in albino rats and their correlation with degenerative processes." Tsitologiia., vol. 50, no. 9, pp. 779-82, Sep. 2008. [PubMed].

V. Khavinson, B. Goncharova, and N. Lapin. "Synthetic tetrapeptide epitalon restores disturbed neuroendocrine regulation in senescence accelerated OXYS rats." Neuroendocrinology Letters, vol. 22, no. 4, pp. 251-254, Aug. 2001. [PubMed].

N. I. Chalisova, M. E. Litivina, M. M. Shchukin, A. G. Drozdov, G. A. Ryzhak, and V. K. Khavinson. "Effect of peptide epitalon on microvascular reactions and their role in age-dependent reorganization of tissues." Bull. Exp. Biol. Med., vol. 141, no. 4, pp. 452-455, May 2006.

N. V. Linke and A. A. Pankova. "Peptide Regulation of Skin Fibroblast Functions during Aging in Vitro." Bull. Exp. Biol. Med., vol. 148, no. 1, pp. 151-155, July 2009. [PubMed].

I. V. Vinogradova, V. V. Ruslova, M. V. Zabezhinskii, V. A. Semenchenko, V. A. Yakovlev, T. S. Zavarykina, A. V. Arutinuyan, M. A. Karasik, A. N. Gorban, and V. Kh. Khavinson. "The Geroprotective Property of Epithalon and Metformin during Aging." Adv. Gerontol., vol. 143, no. 1, pp. 393-432, Dec. 2017. [PubMed].