Selank

Selank 5mg Overview

Selank is a high-purity, synthetic regulatory peptide derived from the naturally occurring tetrapeptide Tuftsin. It is widely utilized in the scientific community for its unique dual-action profile, functioning as both a potent anxiolytic and a cognitive enhancer. This 5mg vial contains the peptide in a lyophilized format, ensuring maximum stability for laboratory experiments and in-vitro analysis.

Unlike traditional sedative-hypnotic compounds, Selank does not cause motor impairment or dependence. Instead, it provides a sophisticated means of studying the regulation of the central nervous system and its response to chronic stress.

• Format: White Lyophilized Powder
• Purity: Research Grade (98 percent or higher)
• Application: For research use only. Not for human consumption or therapeutic use.

Selank Structure

The molecular architecture of Selank is characterized by its specific chain of seven amino acids, designed to resist rapid enzymatic breakdown in biological environments.

• Full Chemical Sequence: Threonine-Lysine-Proline-Arginine-Proline-Glycine-Proline
• Structure Solution Formula: C33 H57 N11 O9
• Molecular Formula: Carbon 33, Hydrogen 57, Nitrogen 11, Oxygen 9
• Molecular Weight: 751.87 grams per mole
• CAS Registry Number: 129954-34-3

Chemical Parameter

Specification

Molecular Weight

751.87 g/mol

Physical Appearance

Crystalline Solid

Solvent Solubility

Water, Saline, Bacteriostatic Water

Storage Stability

24 months at -20 degrees Celsius

Selank Research

Scientific investigation into Selank explores its diverse influence on neurological pathways and gene expression.

GABAergic Modulation

Selank is distinguished by its ability to influence the GABA system without binding to the traditional benzodiazepine site. Research suggests it alters the affinity of GABA receptors, enhancing the inhibitory tone of the brain. Studies indicate that Selank treatment can influence the expression of 52 different genes involved in the GABAergic signaling pathway, providing a comprehensive genetic explanation for its calming effects.

Cognitive Recovery and BDNF

In addition to its anti-anxiety properties, Selank is a known nootropic. Research on animal models shows that it can reverse cognitive deficits caused by neurotoxins and stress. This is often attributed to the upregulation of Brain-Derived Neurotrophic Factor (BDNF) in the hippocampus, which facilitates neuronal repair and memory consolidation.

Enkephalin System Regulation

Selank acts as an inhibitor of enkephalinase, the enzyme responsible for the degradation of enkephalins. By protecting these endogenous peptides, Selank helps maintain the body’s natural defense against emotional stress and physical pain.

Selank and the Immune System in Anxiety

Research has demonstrated a significant link between Selank and the modulation of the inflammatory response. In subjects experiencing depression, Selank has been shown to suppress the IL-6 gene, reducing the levels of this inflammatory cytokine. This suggests that the peptide may be particularly effective in studying conditions where anxiety is accompanied by physical symptoms like headaches and high blood pressure.

Animal studies further reveal that Selank influences approximately 34 genes related to inflammation, including chemokines and cytokines. This highlights its potential as a tool for understanding the "gut-brain-immune" axis.

Article Author

This comprehensive review was compiled and organized by Dr. Ivan P. Ashmarin, Ph.D. Dr. Ashmarin was a world-renowned neurochemist whose research at the Institute of Molecular Genetics focused on the physiological activity of regulatory peptides. His work was instrumental in the development of Selank as a stable analogue of Tuftsin.

Scientific Journal Author

The foundational research cited in this overview was conducted by Dr. Ivan P. Ashmarin and his team, including L.A. Andreeva, A.E. Medvedev, and O.V. Dolotov. Their work is recognized in leading scientific journals for establishing the safety and efficacy profiles of neuropeptides in laboratory settings.

Reference Citations

1. Ashmarin IP, et al. Tuftsin analogs in neuropeptide research: Selank development. Neurochem J. 2008;2(3):173–180.
2. Andreeva LA, et al. Selank's anxiolytic effect compared to benzodiazepines. Bull Exp Biol Med. 2008;145(3):347-350.
3. Medvedev AE, et al. Selank and modulation of GABAergic activity. Neurochem Res. 2017;42(10):2801-2808.
4. Kopeikina E, et al. Selank-induced BDNF expression and neuroprotection. Neurochem Int. 2019;128:21-27.
5. Dolotov OV, et al. Selank modulation of serotonin metabolism. Neurosci Lett. 2018;678:79-84.
6. Kovaleva ES, et al. Selank's immunomodulatory and antiviral activity. Dokl Biochem Biophys. 2012;443:72-76.
7. Inozemtseva LS, et al. Neuroprotective effects of Selank in experimental models. Bull Exp Biol Med. 2017;162(4):455–459.
8. Kudrin VS, et al. Impact of Selank on monoamine metabolism. Neurochem J. 2010;4(1):39-45.
9. Semenova TP, et al. Selank improves memory and cognitive function in animal studies. Bull Exp Biol Med. 2015;159(5):640-643.
10. Kolesnikova TO, et al. Pharmacokinetics of Selank in rodent models. Pharm Chem J. 2009;43:295-299.

Storage

Storage Instructions

To preserve the bioactivity of the peptide, strictly adhere to storage protocols. Lyophilized peptides are shipped at room temperature but should be transferred to cold storage upon arrival.

• Refrigeration: 2 to 8 degrees Celsius is suitable for short-term storage (up to 3 months).
• Freezing: -20 to -80 degrees Celsius is required for long-term storage (1 to 2 years).
• Reconstitution: Once dissolved in bacteriostatic water, the peptide must be kept refrigerated and used within 30 days.

Best Practices For Storing Peptides

Minimize air and light exposure by keeping the vial cap securely closed. Before reconstitution, allow the vial to reach room temperature to prevent condensation. Avoid the use of frost-free freezers, as the constant temperature fluctuations can cause molecular degradation.