Semax Overview
Semax is a high-performance synthetic heptapeptide that serves as a stabilized analogue of the adrenocorticotropic hormone (ACTH) fragment 4-10. Developed through extensive neuropharmacological research, Semax was designed to isolate the potent cognitive and neuroprotective benefits of the natural peptide while completely removing its hormonal properties. This modification ensures that Semax does not stimulate the production of cortisol or other corticosteroids, making it a focused tool for neurological research.
In scientific literature, Semax is classified as a regulatory neuropeptide with a wide array of applications. It is primarily studied for its ability to improve memory consolidation, protect neurons from ischemic damage, and assist the brain in adapting to environmental stressors. By modulating the levels of brain-derived neurotrophic factor (BDNF) and influencing neurotransmitter activity, Semax acts as a comprehensive support system for the central nervous system, particularly in contexts involving cognitive decline, stroke recovery, and mood regulation.
Semax Structure
The chemical design of Semax is focused on longevity and biological precision. The addition of a specific amino acid sequence to the core ACTH fragment prevents the rapid enzymatic degradation that typically occurs with natural peptides. This structural stability allows the compound to exert its effects over a longer duration within the central nervous system.
Structure Solution Formula:
Methionyl-Glutamyl-Histidyl-Phenylalanyl-Prolyl-Glycyl-Proline
Technical Product Specifications
Component
Technical Detail
Peptide Type
Neuropeptide / Nootropic
Amino Acid Sequence
Met-Glu-His-Phe-Pro-Gly-Pro
Molecular Formula
C37H51N9O10S
Molecular Weight
813.92 grams per mole
Solubility Profile
High solubility in aqueous solutions
Stability Form
Lyophilized crystalline powder
Semax Research
Modulation of the Default Mode Network
Research involving functional magnetic resonance imaging (fMRI) has revealed that Semax has a profound impact on the brain’s Default Mode Network (DMN). This network is a complex of brain regions that remain active during periods of wakeful rest. The DMN is critical for maintaining social awareness and environmental monitoring when the brain is not focused on a specific task. By enhancing the connectivity and activity within the DMN, Semax may improve a subject's ability to remain alert and transition quickly from a resting state to a state of high-intensity focus.
Neuroprotection and Ischemic Recovery
Semax has gained significant attention for its role in stroke rehabilitation. Studies indicate that it activates molecular pathways responsible for gene transcription in the brain. Specifically, it regulates 24 genes involved in the vascular system, promoting the health of smooth muscle cells and the formation of new blood vessels. These mechanisms help stabilize mitochondrial function and preserve energy production in neurons, which is vital for preventing cellular death during periods of oxygen deprivation (hypoxia).
Gene Expression and Growth Factors
The cognitive benefits of Semax are largely attributed to its rapid effect on gene expression in the hippocampus and the frontal cortex. Within 20 minutes of administration, research shows a marked increase in the production of Nerve Growth Factor (NGF) and Brain-Derived Neurotrophic Factor (BDNF). These factors are essential for neuroplasticity—the process by which the brain repairs itself and forms new neural pathways. This makes Semax a primary candidate for research into learning enhancement and the treatment of neurodegenerative disorders.
Cognitive Enhancement and Memory
Experimental data suggests that Semax acts as a potent nootropic. It has been shown to prevent the cognitive regression often associated with neurological disorders. By protecting the regions of the brain responsible for planning and information organization, Semax helps maintain mental clarity and concentration. Even at low doses, the peptide appears to optimize the brain's ability to process and retain complex information.
Applications in Mood and Stress Management
By elevating BDNF levels, Semax provides a unique pathway for addressing symptoms of depression and anxiety. Unlike traditional medications that focus solely on serotonin levels, Semax supports the physical health of the brain's neural circuits. This holistic approach to neurochemistry can lead to more resilient stress responses and improved emotional stability in animal models.
Article Author
Dr. Maria V. Korolenko, Ph.D.
Dr. Korolenko is an expert biomedical researcher specializing in the field of neuropharmacology. With a doctorate in molecular biology, her career has focused on the regulation of synaptic activity through synthetic peptides. She is a prolific scientific writer dedicated to translating complex biochemical data into actionable research insights.
Scientific Journal Author
Dr. Nikolai Fedorovich Myasoedov
Dr. Myasoedov is a senior academician at the Russian Academy of Sciences. He is the leading pioneer in the development of Semax and Selank. His research into peptide-mediated neuroprotection has set the global standard for understanding how regulatory peptides influence cognitive processes and stress adaptation.
Reference Citations
- Ashmarin, I.P., et al. (1997). Semax: biological activity and clinical application. Biochemistry (Moscow).
- Myasoedov, N.F., et al. (2002). Semax, a synthetic analog of ACTH (4-10), as a new class of neuroprotective peptides. Pathophysiology.
- Andreeva, L.A., et al. (2000). Semax regulates brain-derived neurotrophic factor (BDNF) expression in rat hippocampus. Neuroscience and Behavioral Physiology.
- Ashmarin, I.P., & Kamensky, A.A. (1999). Semax and its cognitive effects in animal models. Journal of Neurochemistry.
- Dolotov, O.V., et al. (2006). Effects of Semax on dopamine and serotonin turnover. Neuroscience and Behavioral Physiology.
- Andreeva, L.A., et al. (2001). Neuroprotective properties of Semax in ischemia models. Neuroscience Research.
- Ashmarin, I.P., et al. (2005). Semax as a regulator of stress-induced gene expression. Biochemistry (Moscow).
- Inozemtseva, L.S., et al. (2015). Clinical application of Semax in cognitive impairment. Zhurnal Nevrologii i Psikhiatrii.
- Dolotov, O.V., et al. (2011). Semax effects on neurotrophin signaling. Neuroscience Letters.
- Myasoedov, N.F. (2018). Peptide regulation of cognitive processes: focus on Semax. Neurochemical Journal.
Storage
Lyophilized Powder Stability
Peptides are delivered in a freeze-dried (lyophilized) state, which ensures their stability during the shipping process. In this form, Semax can be kept at room temperature for several months without losing its biochemical integrity. However, for maximum longevity, it should be stored in a cool, dark environment away from direct sunlight.
Reconstitution and Cold Chain Management
Once the peptide is mixed with bacteriostatic water, its shelf life decreases. The reconstituted solution must be refrigerated at 2 to 8 degrees Celsius. At these temperatures, the solution will remain stable for up to 30 days. It is crucial to avoid freezing the solution once it has been reconstituted, as ice crystals can physically damage the peptide structure.
Long-Term Research Storage
For long-term storage of several years, the lyophilized powder should be placed in a freezer at -20 or -80 degrees Celsius. This stops all molecular degradation. Researchers should ensure that the storage unit is not a "frost-free" model, as the temperature cycles in such units can compromise the product.
Best Practices for Handling
- Temperature Sensitivity: Always allow vials to reach room temperature before opening to prevent moisture condensation.
- Light Protection: Use amber vials or keep containers in a dark box to prevent UV-induced degradation.
- Oxidation Prevention: Keep the vial sealed tightly and minimize the time the product is exposed to the air.
- Aliquoting: Divide the powder into smaller portions if the entire vial will not be used at once, reducing the number of times the primary stock is exposed to temperature changes.
Free Reconstitution Solution automatically added to your cart with each order.
